Fig. 5.
Knockdown of Glra1 eliminates GlyRα1 input to PV5 RGCs at luminance increments. A: representative eIPSCs evoked by the offset of a dark spot (schematic, bottom) from PV5SC (Ai; n = 5) and PV5Glra1-KD (Aii; n = 7) RGCs in control solution (black traces), in the presence of PTX (dark gray traces), and in the presence of both PTX and strychnine (light gray traces). B: in control (Bi) the charge transfer (Q) does not differ across PV5WT, PV5SC, or PV5Glra1-KD groups, whereas the presence of PTX (Bii) significantly reduces the charge transfer in PV5Glra1-KD compared with PV5SC RGCs. *P < 0.05.