Table 1. Physiological parameters measured before and after cardiac arrest in rats (mean±s.d.).
| Variable |
Cardiac Arrest (6 minutes) |
|||
|---|---|---|---|---|
| Before | After | Before | After | |
| D-cycloserine (n=10) | Vehicle (Saline, n=8) | |||
| Age (days) | 68.9±4.3 | 68.5±5.5 | ||
| Body Weight (g) | 284.7±10.7 | 283.7±17.6 | ||
| pH | 7.46±0.03 | 7.50±0.07 | 7.44±0.02 | 7.46±0.02 |
| PCO2 (mm Hg) | 38±2 | 38±2 | 39±2 | 41±3 |
| PO2 (mm Hg) | 119±7 | 135±44 | 122±7 | 128±14 |
| HCO3− (mmol/L) | 27.3±1.8 | 29.8±4.2 | 26.2±1.5 | 29.1±2.5 |
| Base Excess | 3.5±2.1 | 6.7±5.3 | 2.1±1.6 | 5.3±2.6 |
| HCT | 48.2±2.0 | 48.5±1.5 | ||
| MABP (mm Hg) | 120±16 | 96±14 | 116±10 | 93±17 |
| Tbrain (°C) | 36.6±0.2 | 36.7±0.2 | 36.7±0.2 | 36.6±0. |
| Trec (°C) | 36.8±0.2 | 37.0±0.3 | 36.8±0.2 | 36.8±0.5 |
| Plasma glucose (mg/dL) | 144±16 | 143±22 | ||
| Variable |
Cardiac Arrest (8 minutes) |
|||
| Before | After | Before | After | |
| |
D-cycloserine (n=7) |
Vehicle (Saline, n=6) |
||
| Age (days) | 74.0±6.4 | 68.8±6.1 | ||
| Body Weight (g) | 299.2±24.3 | 275.4±16.5 | ||
| pH | 7.45±0.01 | 7.48±0.04 | 7.44±0.03 | 7.50±0.02 |
| PCO2 (mm Hg) | 38±1 | 38±2 | 38±3 | 38±2 |
| PO2 (mm Hg)a | 112±10 | 116±34 | 119±10 | 102±2 |
| HCO3− (mmol/L) | 26.3±1.2 | 28.8±2.9 | 25.8±1.3 | 30.0±2.1 |
| Base Excess | 2.1±1.3 | 5.1±3.6 | 1.7±1.5 | 6.8±2.4 |
| HCT | 47.8±3.5 | 46.6±0.1 | ||
| MABP (mm Hg)a | 109±11 | 72±10 | 106±30 | 74±17 |
| Tbrain (°C)a | 36.9±0.3 | 36.9±0.4 | 36.8±0.3 | 36.8±0.2 |
| Trec (°C)a | 36.9±0.4 | 37.1±0.3 | 37.0±0.1 | 37.4±0.4 |
| Plasma glucose (mg/dL) | 144±24 | 124±16 | ||
a
P<0.05 vs 6 minutes Cardiac Arrest.