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. 2014 Sep 24;34(12):1887–1897. doi: 10.1038/jcbfm.2014.156

Figure 1.

Figure 1

Insulin-like growth factor-1 (IGF-1) deficiency impairs adaptation of cerebrovascular autoregulation to hypertension. (A) Serum levels of IGF-1 of control (TBG-eGFP-AAV8) and IGF-1-deficient (TBG-iCre-AAV8) mice after viral injection (n=20 to 25 for each group). In the mouse model used, IGF-1 levels are identical before the injection.22 (B) Effect of chronic infusion of angiotensin II on systolic blood pressure in control and IGF-1-deficient mice. Data are mean±s.e.m. (n=20 to 25 for each group) *P<0.05 vs. Control; #P<0.05 vs. IGF-1 deficient. (C and D) Relationship between systolic blood pressure and cerebral blood flow (CBF) in normotensive control, hypertensive control (control+Ang II) and normotensive IGF-1-deficient (Igf1f/f+TBG-iCre-AAV8) and hypertensive IGF-1-deficient mice (Igf1f/f+TBG-iCre-AAV8+AngII). Data are mean±s.e.m. (n=8 for each data point). In control mice, CBF is statistically different from the value at 100 mm Hg at pressure values of <60 and >140 mm Hg, indicating the autoregulatory range. In control hypertensive mice, there was an expansion of the autoregulated range to high pressure values (C), indicating an adaptive response (*P<0.05 vs. Control at 160 mm Hg), which was completely absent in IGF-1-deficient hypertensive mice (D). The blood pressure-CBF curves of normotensive control and normotensive IGF-1-deficient mice did not differ significantly.