Table 1. Regional distribution volumes of ¹¹C-LY2795050 in baseline and blocking scans.

Regions	Baseline (n=16)			Blocking with naltrexone (n=16)	Minimum scan duration (minutes)
	1TC (%COV)	2TC (%COV)	MA1 (%COV)	MA1 (%COV)	2TC	MA1
Amygdala	3.76 (13%)	3.95 (13%)	3.95 (14%)	1.62 (15%)	60	70
Insula	3.09 (9%)	3.41 (10%)	3.41 (10%)	1.68 (14%)	70	50
Ant. cingulate cortex	2.98 (10%)	3.23 (11%)	3.25 (10%)	1.71 (13%)	60	50
Globus pallidus	2.86 (11%)	3.11 (12%)	3.11 (12%)	1.90 (14%)	50	60
Putamen	2.65 (10%)	3.00 (11%)	2.94 (10%)	1.81 (14%)	70	50
Temporal cortex	2.44 (9%)	2.74 (11%)	2.71 (10%)	1.70 (13%)	70	60
Frontal cortex	2.34 (9%)	2.66 (11%)	2.63 (10%)	1.64 (14%)	70	50
Occipital cortex	2.24 (8%)	2.58 (10%)	2.54 (9%)	1.77 (12%)	70	60
Hippocampus	2.07 (11%)	2.31 (12%)	2.35 (12%)	1.58 (14%)	60	50
Caudate	1.99 (16%)	2.19 (17%)	2.16 (16%)	1.40 (19%)	60	50
Post. cingulate cortex	1.93 (13%)	2.24 (17%)	2.24 (12%)	1.61 (13%)	70	60
Thalamus	2.03 (10%)	2.14 (10%)	2.18 (11%)	1.78 (14%)	30	50
Centrum semiovale	1.90 (8%)	2.30 (10%)	2.28 (10%)	1.86 (15%)	70	70
Cerebellum	1.76 (8%)	1.96 (9%)	1.95 (8%)	1.57 (13%)	70	50

MA1, multilinear analysis-1; 1TC, one-tissue compartment model; 2TC, two-tissue compartment model.

%COV is variability across subjects.