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. 2014 Sep 11;135(1):304–308. doi: 10.1038/jid.2014.311

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Copyright © 2015 The Society for Investigative Dermatology, Inc

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Clinical manifestations of autosomal dominant multiple self-healing palmoplantar carcinoma (MSPC). (a) Pedigree of a five-generation Tunisian family segregating autosomal dominant MSPC (▪ affected man, □: healthy man, ○: healthy woman, ●: affected woman, : unknown phenotype, *: propositi having developed cancer, underlined: genotyped individual). Clinical histories and physical examinations were undertaken after obtaining informed written consent from all patients and Institutional Review Board approval. (b) Six-week-old primary plantar keratoacanthoma (KA) with a ulcerative-nodular aspect (IV:13). (c) Higher magnification of tumor (20 mm). (d) Evolution of primary KA toward a verrucous tumor (IV:5). (e) Atrophic scar after complete regression of primary KA (IV:5). (f) Multiple lesions in palmar skin showing over 12 KAs at various phases of development ranging from maturation, regression, to final pitted-scar stage (IV:20). (g) Subungual lesion on the thumb. (h, i) Unilateral conjunctival KA (IV:13 and IV:14). Photographs are reproduced with permission from patients.

Inline graphic — Clinical manifestations of autosomal dominant multiple self-healing palmoplantar carcinoma (MSPC). (a) Pedigree of a five-generation Tunisian family segregating autosomal dominant MSPC (▪ affected man, □: healthy man, ○: healthy woman, ●: affected woman, : unknown phenotype, *: propositi having developed cancer, underlined: genotyped individual). Clinical histories and physical examinations were undertaken after obtaining informed written consent from all patients and Institutional Review Board approval. (b) Six-week-old primary plantar keratoacanthoma (KA) with a ulcerative-nodular aspect (IV:13). (c) Higher magnification of tumor (20 mm). (d) Evolution of primary KA toward a verrucous tumor (IV:5). (e) Atrophic scar after complete regression of primary KA (IV:5). (f) Multiple lesions in palmar skin showing over 12 KAs at various phases of development ranging from maturation, regression, to final pitted-scar stage (IV:20). (g) Subungual lesion on the thumb. (h, i) Unilateral conjunctival KA (IV:13 and IV:14). Photographs are reproduced with permission from patients.