Due to the high prevalence of anxiety and restlessness in younger women, the herbal anxiolytic drug Silexan and oral contraceptives are likely to be co-administered. Therefore, it is important to investigate the interaction potential of Silexan with oral contraceptives.

This randomised, double-blind, placebo-controlled crossover trial showed that Silexan did not relevantly affect the pharmacokinetic properties of a combination oral contraceptive containing ethinyl estradiol and levonorgestrel.

Silexan therefore does not decrease the efficacy of currently used combination oral contraceptives.