Table 2.
Comparison of serum levels of creatine kinase (CK), lactate dehydrogenase (LDH), total cholesterol (TC) and triglycerides (TG) in the different studied groups
| Parameter | Group I (normal controls) (n = 8) | Group II (non-treated hypercholesterolemic rats with acute myocardial infarction) (n = 8) | Group III (aspirin-pretreated hypercholesterolemic rats with acute myocardial infarction) (n = 8) | Group IV (clopidogrel-pretreated hypercholesterolemic rats with acute myocardial infarction) (n = 8) | Group V (combined aspirin and clopidogrel pretreated hypercholesterolemic rats with acute myocardial infarction) (n = 8) | F and P |
|---|---|---|---|---|---|---|
| CK (U/l) | ||||||
| Min.–max. | 8.90–12.30 | 32.70–44.80 | 18.90–24.20 | 19.8–23.30 | 14.10–17.50 | 213.66 and 0.0081** |
| Mean ± SD | 10.63a ± 1.11 | 40.56b ± 3.99 | 21.23c ± 1.94 | 21.11c ± 1.20 | 16.07d ± 1.19 | |
| LDH (U/l) | ||||||
| Min.–max. | 225.70–263.30 | 483.90–590.30 | 305.40–360.20 | 310.50–365.30 | 285.40–330.10 | 22.93 and 0.0051** |
| Mean ± SD | 196.37a ± 90.47 | 535.38b ± 35.90 | 329.95c ± 19.30 | 332.95c ± 19.80 | 271.80d ± 98.11 | |
| TC (mg/dl) | ||||||
| Min.–max. | 82–110 | 130–170 | 128–165 | 132–158 | 129–163 | 18.11 and 0.0013** |
| Mean ± SD | 87.62a ± 30.26 | 151.25b ± 14.07 | 148.13b ± 12.58 | 147.14b ± 9.77 | 140.63b ± 14.52 | |
| TG (mg/dl) | ||||||
| Min.–max. | 45–81 | 90–151 | 82–148 | 84–143 | 87–146 | 16.14 and 0.0046** |
| Mean ± SD | 59.12a ± 25.68 | 133.75b ± 20.22 | 127.88b ± 25.73 | 116.88b ± 21.97 | 121.00b ± 21.86 | |
n number of rats
** High statistical significance
a, b, c, d Letters indicate statistically significant difference