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. 2014 Dec 4;5:28. doi: 10.1186/s13100-014-0028-y

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© Théron et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ovarian somatic piRNA pathway in Drosophila. After being spliced and transferred to nuclear Dot COM, flam transcripts are exported to cytoplasmic Yb bodies, believed to be the site of piRNA processing. Their processing in piRNAs requires 5′ end cleavage, loading onto Piwi protein and 3′ end trimming. The mature Piwi pi-RISC is then imported into the nucleus to silence target transposons by Transcriptional Gene Silencing (TGS).