Table 2.
Inhibitory potential of a variety of HIV-1 inhibitors towards WT and mutant virus strains containing one N -glycan deletion in gp41
| HHA (nM) | UDA (nM) | AH (nM) | 2G12 (nM) | PRM-S ( μM) | T-20 (nM) | AMD3100 (nM) | |
|---|---|---|---|---|---|---|---|
| WT | 0.9 ± 0.2 | 25 ± 3 | 5.2 ± 1.0 | 1.1 ± 0.2 | 4.8 ± 0.4 | 340 ± 141 | 3.5 ± 0.6 |
| N611Q | 1.6 ± 0.3 | 32 ± 6 | 5.4 ± 0.2 | 0.9 ± 0.2 | 5.3 ± 0.1 | 247 ± 177 | 2.5 ± 0.7 |
| N625Q | 1.4 ± 0.3 | 27 ± 5 | 8.1 ± 1.2 | 1.3 ± 0.2 | 4.5 ± 0.8 | 702 ± 255 | 2.9 ± 1.1 |
| N637Q | 3.7 ± 1.4 | 57 ± 24 | 15 ± 8 | 3.0 ± 2.0 | 5.3 ± 0.4 | 664 ± 454 | 7.6 ± 5.0 |
| N674Q | 1.3 ± 0.4 | 32 ± 11 | 8.3 ± 0.8 | 1.9 ± 0.5 | 5.2 ± 0.2 | 1530 ± 1201 | 3.8 ± 1.5 |
Values represent the EC50’s (50% effective concentration) of the test compounds expressed in nM or μM.
Data are the means ± SEM of at least 2 to 3 independent experiments.