Table 1.

Summary of key assumptions considered in the cost-effectiveness model

Parameter	Key assumptions
Model structure	Two-stage Markov cohort model
CE model time horizon	Lifetime
Model cycle	Monthly
CV mortality for SoC	SHIFT data by applying Gompertz survival model
HR for CV mortality of ivabradine vs SoC	0.90 (0.80 – 1.03) based on SHIFT data
Rate hospitalization	SHIFT data by applying Poisson model
Rate ratio for hospitalization of ivabradine vs SoC	0.83 (0.78 – 0.93) based on SHIFT data
Length of hospitalization	Local data (based on experts’ opinion)
Utility data	SHIFT data by applying mixed regression model
NYHA data	SHIFT data by applying adjusted ordered logistic regression
Ivabradine treatment effect	Cardiovascular endpoint
Ivabradine use (years)	Lifelong
Cost discount rate per annum	3.5%
Effects discount rate per annum	3.5%
Resource utilization and unit costs	Local data (government gazette and experts’ opinion)
Outcome mesaures	QALYs, LYs, ICER per QALY and per LY gained, lifetime total cost

CE: cost-effectiveness; HR: hazard ratio; QALYs: quality-adjusted life years; LYs: life years; ICER: incremental cost effectiveness ratio; CV: cardiovascular; NYHA: New York Heart Association.