Table 2.
M. tuberculosis rpoB wild-type and mutant isolates analyzed using the rpoB probe array
| Clinical isolates | Resistance phenotype | MIC (μg/ml) | Mutated codon(s) |
|---|---|---|---|
| 1 | L | 32 | WT |
| 2 | L | 64 | 516 A → G |
| 3 | L | 64 | 516 A → G |
| 4 | L | 128 | 513 A → C |
| 5 | H | 128 | 526 C → G |
| 6 | H | 256 | 513 A → C |
| 7 | H | 256 | 531 C → T |
| 8 | H | ND | 531 C → T |
| 9 | H | ND | 531 C → T |
| 10 | H | ND | 531 C → T |
| 11 | H | ND | 531 C → T |
| 12 | H | ND | 531 C → T |
| 13 | H | ND | 531 C → T |
| 14 | H | ND | 531 C → T |
| 15 | H | ND | 531 C → T |
| 16 | H | ND | 531 C → G |
| 17 | H | ND | 526 C → T |
| 18 | H | ND | 516 A → G |
| H37Rv | S | 0.25 | WT |
S, susceptible to rifampicin; L, low-level resistance to rifampicin (resistant to 50 μg/ml rifampicin); H, high-level resistance to rifampicin (resistant to 250 μg/ml rifampicin); ND, not determined; WT, wild-type.