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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Semin Oncol. 2014 Oct 7;41(6):848–859. doi: 10.1053/j.seminoncol.2014.09.013

Figure 3.

Figure 3

The effects of radiation with and without the Chk1/2 inhibitor AZD7762 (100 nM, added 1 hr prior to and 24 hr post-radiation) on radiation-induced cell killing and mitotic catastrophe. In this study the influence of p53 on Chk1/2 inhibition/radiation response was evaluated using a H460 lung cancer cell line (wild type p53) as opposed to H460 cells containing a dominant negative p53 construct (H460 DN p53). Wild type p53 cells (A & C) were not sensitized by the combination of AZD7762 and radiation; whereas, the radiosensitivity H460 DN p53 cells were significantly enhanced by AZD7762 (B,) as well as DNA damage as measured by mitotic catastrophe (D). (Adapted from reference (26) with permission)