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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Semin Oncol. 2014 Oct 7;41(6):848–859. doi: 10.1053/j.seminoncol.2014.09.013

Figure 5. Serum, tissue, and tumor levels of WR-2721 (Amifostine) in Fischer 344 rats as a function of time after an i.p. injection.

Figure 5

Notice that normal tissue levels rapidly achieve mM concentrations of WR-2721; whereas, tumor levels are quite low initially. With time tumor levels gradually increase, while normal tissue levels begin to decrease. This study demonstrates that chemical radioprotector tissue concentrations in the mM range can be achieved quickly. Further the study underscores the importance of the timing of radiation exposure with within 15-30 min after injection to take advantage of the differential concentration of WR-2721 in normal as opposed to tumor tissue. (Adapted from reference (64), with permission)