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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Semin Oncol. 2014 Oct 7;41(6):848–859. doi: 10.1053/j.seminoncol.2014.09.013

Figure 7. The effect of the radioprotector Tempol on oral mucositis resulting from fractionated irradiation and cisplatin (CDDP).

Figure 7

To measure ulceration tongues were removed from the various groups and stained with Toluidine blue. Ulcerations were clearly present in tongues from mice treated with the combination of CDDP and radiation (Panel A, second row, marked by arrows). Tempol either delivered systemically or topically afforded near complete protection (A, third and fourth rows). Using the same Tempol/CDDP/radiation protocol as used in A, SCCVII tumor regrowth for the various groups is shown in B. Tempol did not interfere with CDDP mediated enhancement of radiation. (Adapted from reference (58), with permission).