TABLE 2.
Delivery characteristics and neonatal outcomes of those with early vs later PPROM
| Characteristic | Early PPROM (n = 275) |
Later PPROM (n = 1256) |
P value |
|---|---|---|---|
| Rupture-to-delivery interval, d, mean ± SD |
20.0 ± 20.2 | 10.4 ± 10.7 | < .001 |
| Gestational age at delivery, wks, mean ± SD |
26.6 ± 2.5 | 30.1 ± 2.2 | < .001 |
| Received antenatal corticosteroids | 272 (98.9) | 1226 (97.6) | .180 |
| Placental abruption | 29 (10.6) | 99 (7.9) | .148 |
| Chorioamnionitis | 45 (16.4) | 151 (12.0) | .051 |
| Cesarean delivery | 127 (46.2) | 456 (36.3) | .002 |
| Postpartum endometritis | 24 (8.7) | 74 (5.9) | .082 |
| Maternal length of hospitalization, d, mean ± SD |
19.1 ± 17.1 | 12.5 ± 11.2 | < .001 |
| Male fetus | 153 (55.6) | 667 (53.1) | .446 |
| Birthweight, g, mean ± SD | 930 ± 415 | 1481 ± 444 | < .001 |
| Culture-proven sepsis | 111 (40.4) | 143 (11.4) | < .001 |
| Necrotizing enterocolitis | |||
| Any severity | 40 (14.6) | 91 (7.3) | < .001 |
| Severe (stage 2 or 3) | 22 (8.0) | 43 (3.4) | .001 |
| Retinopathy of prematurity | 138 (50.2) | 190 (15.1) | < .001 |
| Bronchopulmonary dysplasia | 136 (49.5) | 127 (10.1) | < .001 |
| Neonatal seizures | 15 (5.5) | 15 (1.2) | < .001 |
| Intraventricular hemorrhage | |||
| Any severity | 76 (29.5) | 237 (19.4) | < .001 |
| Severe (grade III or IV) | 15 (5.8) | 13 (1.1) | < .001 |
| Periventricular leukomalacia | 10 (3.9) | 16 (1.3) | .004 |
| Death prior to initial hospital discharge |
46 (16.7) | 31 (2.5) | < .001 |
| Composite severe neonatal morbiditya |
208 (75.6) | 274 (21.8) | < .001 |
Unless otherwise specified, data are listed as n (percentage).
PPROM, preterm premature rupture of membranes.
a
Diagnosis of sepsis, bronchopulmonary dysplasia, severe grade III or IV intraventricular hemorrhage, periventricular leu-komalacia, severe stage 2 or 3 necrotizing enterocolitis, and/or death.
Manuck. Outcomes following early PPROM. Am J Obstet Gynecol 2014.