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Therapeutic targets of the HCV replication cycle.
Notes: DAA viral target sites in advanced clinical development are numbered 1–3. Reprinted from Clin Gastroenterol Hepatol, 12(5), Schmidt WN, Nelson DR, Pawlotsky JM, et al., Direct acting antiviral agents and the path to interferon independence, 728–737, Copyright 2014, with permission from Elsevier.38
Abbreviations: DAA, direct-acting antiviral agent; ER, endoplasmic reticulum; HCV, Hepatitis C virus; LD, luminal domain.
