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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Nat Chem. 2014 Dec 15;7(1):38–44. doi: 10.1038/nchem.2131

Figure 1. Bioactive amines, the synthesis of amines from alkynes, and the reductive hydroamination cascade strategy.

Figure 1

a, Representative alkaloids and drugs demonstrating the ubiquitous nature of amines in bioactive organic molecules. b, Catalytic hydroamination of alkynes to generate three product classes. c. Contrasting reactivities of vinyl- and alkylcopper intermediates required to achieve a reductive hydroamination cascade.