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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 Aug 6;133(1):248–55.e1-10. doi: 10.1016/j.jaci.2013.06.018

Figure 3.

Figure 3

GRAIL functional connections between the 80 predictive SNPs. Six SNPs with no nearby genes defined by GRAIL are not shown. GRAIL identified six pairs of SNPs that implicated the same genes; only one SNP from each these 6 pairs is shown in the figure. The regions (SNPs; outer ring) and genes (inner ring) are optimally ordered to display connections with a minimal number of intersections. Only the genes with PGRAIL-values < 0.05 have connections displayed. The thickness and redness of the connectors reflects the significance of the connections. Three clusters of β-defensin genes are the most connected sets.