Table 2.
High scoring regions from the GRAIL analysis, sorted by the GRAIL P-value. PGWAS is the P-value from the FEV1/FVC GWAS in the Hutterites; Beta (SE) is that of the predictive SNP in the regression model for the 865 Hutterites; and PGRAIL is the region’s P-value given by GRAIL. The last column shows the candidate gene identified by GRAIL.
| SNP | Chr. | NCBI36 Position | PGWAS | Beta (SE) | PGRAIL | Implicated Gene |
|---|---|---|---|---|---|---|
| rs365548 | 20 | 185618 | 5.61E-04 | 0.003 (0.046) | 6.4E-04 | DEFB129, C20orf96 |
| rs2921026 | 8 | 8384658 | 6.14E-04 | −0.133 (0.046) | 6.6E-04 | DEFB107A |
| rs4815436 | 20 | 25521423 | 9.45E-04 | 0.181 (0.069) | 9.7E-04 | DEFB115, DEFB116, DEFB123, DEFB124 |
| rs854679 | 17 | 31382952 | 3.40E-07 | −0.049 (0.059) | 0.020 | CCL18 |
| rs1570846 | 10 | 43776486 | 7.06E-04 | −0.139 (0.055) | 0.037 | CXCL12 |
| rs7216399 | 17 | 16797303 | 5.96E-04 | −0.065 (0.054) | 0.043 | TNFRSF13B |