FIG. 4.

CCN2(IV) increases phenylephrine vascular contractile response. (A) Concentration–response curve to Phe (1 nM–30 μM) in aortic segments treated 1 h with 50 ng/ml CCN2(IV), in the absence or in presence of apocynin (0.3 mM) or ML-171 (1 μM). (B) Concentration–response curve to Phe (1 nM–30 μM) in aortic segments treated 1 h with 50 ng/ml CCN2(IV), in the presence or absence (E−) of endothelium. Data expressed as mean±SEM of four to eight experiments. **p<0.01, ***p<0.001 versus each control situation. Phe, phenylephrine.