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PrxII deficiency enhances LPS-induced c-Fos and NFATc1 expression through JNK pathway. (A–C) Preosteoclasts were serum starved for 12 h and stimulated with 1 μg/ml LPS for the indicated time. Whole-cell extracts were harvested from cultured cells and subjected to SDS-PAGE and Western blot analysis to detect NFATc1, c-Fos, and p-JNK. The detection of β-actin and JNK in each sample serves as a loading control. All values are the mean±SD of three independent experiments. *p<0.05.
