FIG. 7.

PrxII-deficient mice show enhanced osteoclast formation by LPS in vivo. LPS or PBS was directly injected into calvariae. After 6 days, mice were sacrificed. (A) Extracted calvariae were fixed in 4% paraformaldehyde for 24 h at 4°C and then stained for TRAP. (B) Micro-CT images of whole calvariae are presented in which dark spots indicate eroded surfaces. n=3; **p<0.01, ***p<0.005. PBS, phosphate-buffered saline.