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. 2015 Jan 1;22(1):63–77. doi: 10.1089/ars.2013.5748

FIG. 8.

FIG. 8.

PrxII-deficient mice show accelerated bone loss by LPS challenge. Twelve-week-old PrxII+/+ and PrxII−/− mice were injected i.p. with 5 mg/kg LPS on days 0 and 4 and then sacrificed on day 8. (A) BMD (g/cm2) of femur from PrxII+/+ and PrxII−/− mice was analyzed by DXA. (B–F) BV/TV, % (B), Tb.Th (C), Tb.N (D), SMI (E), and three-dimensional micro-CT images of the distal metaphyses of the femora (F). n=7; *p<0.05, **p<0.01. Scale bar 1.0 mm. BMD, bone mineral density; BV/TV, bone volume per tissue volume; DXA, dual X-ray absorptiometry; SMI, structure model index; Tb.N, trabecular number; Tb.Th, trabecular thickness.