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| M14 cells | pHER3 | pAKT | pERK |
|---|---|---|---|
| Control | 1 | 1 | 1 |
| PLX4032 alone | 0.3667 | 1.8645 | 0.0524 |
| PLX4032 + NRG1 | 3.9447 | 11.211 | 0.0539 |
| PLX4032 + NRG1 + Lapatinib | 1.0666 | 1.7863 | 0.0571 |
• NRG1 activates pHER3 and pAKT in the presence of PLX4032.
• Lapatinib blocks NRG1-induced pHER3 and pAKT activation.
