Figure 1.

Reported chromatin modification activities of the ANP32 family. Each mammalian ANP32 protein is suggested to modify transcription by regulating chromatin, but by different means. A: ANP32A, either alone or as part of the INHAT complex, is recruited to specific regions of DNA by transcription factors. Here it binds histone-H3 tails and inhibit their modification ^49,50. B: ANP32B is recruited by KLF5 to maintain promoter-specific histone occupancy. Abolishing the KLF5-ANP32B interaction correlates with promoter accessibility and transcriptional activation ⁵⁵. C: ANP32E specifically removes nucleosomes containing variant histone H2A.Z, likely as a means of targeted regulation of transcription ²⁹. DNA-binding transcription factors that may target ANP32E to particular promoters are yet to be identified.