Table 1.
Metabolic fluxes (MFs) of mouse organs/tissues.
| Organ/tissue | MF | (μmol/min/kg)1 | Reference |
|---|---|---|---|
| Brain | ϕ GLY→G6P | 2.0 | (Kim et al. 2007) |
| ϕ PYR→LAC | 469.8 | (Kim et al. 2007) | |
| Heart | ϕ GLY→G6P | 160.0 | (Kim et al. 2007) |
| ϕ PYR→LAC | 352.0 | (Kim et al. 2007) | |
| ϕ TG→GLR | 16.0 | (Kim et al. 2007) | |
| Liver | ϕ GLC→G6P | 73.12 | (Mulligan and Tisdale 1991) |
| ϕ G6P→GAP | 73.13 | (Kim et al. 2007) | |
| ϕ GAP→PYR | 146.23 | (Kim et al. 2007) | |
| ϕ PYR→LAC | 140.0 | (Kim et al. 2007) | |
| ϕ G6P→GLY | 66.0 | (Kim et al. 2007) | |
| ϕ GLY→G6P | 305.42 | (Chacko et al. 2012) | |
| ϕ TG→GLR | 2.7 | (Kim et al. 2007) | |
| ϕ AcoA→FFA | 74.7 | (Kim et al. 2007) | |
| ϕ PYR→ACoA | 0.0 | (Kim et al. 2007) | |
| GI | ϕ PYR→LAC | 100.0 | (Kim et al. 2007) |
| Skeletal muscle | ϕ LAC→PYR | 44.4 | (Kim et al. 2007) |
| ϕ GLY→G6P | 6.2 | (Kim et al. 2007) | |
| ϕ TG→GLR | 6.5 | (Kim et al. 2007) | |
| Adipose tissue | ϕ PYR→LAC | 3.3 | (Kim et al. 2007) |
| ϕ LAC→PYR | 0.9 | (Kim et al. 2007) | |
| ϕ FFA→TG | 138.44 | (Kim et al. 2007) |
All fluxes otherwise indicated by 2, 3 and 4 are calculated using the assumption that the metabolic fluxes (MFs) (per unit organ/tissue mass) in mouse and human are similar.
The ϕGLC→G6P and ϕGLY→G6P in the mouse liver were obtained using isotope tracers.
1per kg of organ weight.
2Experimental data.
3The relationships of MFs for ϕG6P→GAP (=ϕGLC→G6P) and ϕGAP→PYR (=2xϕGLC→G6P) in mouse liver were based on the fluxes in human liver.
4The relationship of MFs for ϕFFA→TG (=0.2ϕTG→FFA) in mouse adipose tissue was based on the fluxes in human adipose tissue. 20% of the FFA resulted from lipolysis reesterified to TG.