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. 2014 Sep 28;2(9):e12155. doi: 10.14814/phy2.12155

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Adenosine levels are elevated in hyperoxic lung injury. Wild‐type mice were exposed to either room air or hyperoxia for 72 h (n = 14 for room air, n = 17 for hyperoxia). BALF analysis showed increase in protein concentration (A), cell count (B), and cytokines IL‐6 (C) and CXCL1 (D) indicating pulmonary edema and inflammatory cell infiltration. Adenosine concentration in the alveolar lining fluid (ALF) was found to be elevated approximately threefold in mice exposed to hyperoxia (E) (n = 10 for room, n = 13 for hyperoxia).