Figure 2.

Loss of CD73 adenosine production worsens pulmonary edema in hyperoxic lung injury. CD73^−/− mice were exposed to room air or 95% oxygen environment for 72 h (n = 12 for each group). BALF analysis showed decreased adenosine concentrations in CD73^−/− mice in room air and hyperoxia (A). CD73^−/− mice had no change in BALF cell count in hyperoxia (B) but did have an increase in BALF protein concentration (C) indicating worsened pulmonary edema. Histology demonstrated increase in fluid accumulation perivascularly in hyperoxia compared to room air, and exaggerated perivascular fluid in CD73^−/− mice with red blood cell extravasation (black arrows) (D).