TABLE B Study Characteristics for the Individual DTI Studies Examined in This Meta-Analysis
| Reference | MR Specifications | Acquisition Voxel Size (mm) Reconstruction Voxel Size (mm) | No. Directions | Duration of DTI | Software Package Used for DTI Pre/Post Processing and Analysis | Number of ROIs |
|---|---|---|---|---|---|---|
| Adamson et al. (2013) | 3T Philips Medical Systems scanner | Echoplanar imaging sequence: TR = 8799ms; TE = 88ms; flip angle = 90°; slice thickness = 2mm; 72 contiguous slices; FOV = 180 × 180 mm2; b = 1000s/mm2 | 33 | FMRIB Software Library (TBSS, FNIRT) | Whole brain | |
| Borich et al. (2013)/ Virji-Babul et al. (2013) | 3T Philips Achieva | Single shot echoplanar imaging sequence; TR = 7013ms; TE = 60ms; FOV = 224 × 224mm; 70 slices; voxel dimension = 2.23; b = 700s/mm2 | 60 | 7 mins | ExploreDTI | Left and right anterior corona radiata, left and right thalamic radiation, right forceps minor, right inferior longitudinal fasciculus, right and left inferior fronto-occipital fasciculus, fornix, left subcallosal cortex, right thalamus, genu CC |
| Caeyenberghs et al. (2010/2011) | 3T Phillips Intera with 8-channel head coil | Diffusion weighted single shot spin-echo echoplanar imaging with data acquisition matrix = 112 × 112; FOV = 220 × 220 mm2; TR = 7916 ms, TE = 68 ms, parallel imaging factor 2.5, and 68 contiguous sagittal slices (slice thickness = 2.2 mm; voxel size = 2 × 2 × 2.2 mm3) | 45 | ExploreDTI | Corpus callosum, corticospinal tract, superior cerebellar peduncle, inferior cerebellar peduncle, cerebral peduncle, anterior corona radiate, ALIC, PLIC | |
| Chu et al. (2010)/ Wu, et al. (2010)a Yallampalli et al. (2010)/ Wilde et al. (2008) | 3T Philips Achieva | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 256 mm; TR = 6318 ms; TE = 51 ms; 70 slices, slice thickness = 2 mm, 0 mm gap; b = 0, and 1000 s/mm2 | 30 | 5 mins | Philips PRIDE registration tool and DTIStudio | Right and left cingulumbundle, fornix, total CC, 3 tissue masks: White Matter, Grey Matter, and CerebroSpinal Fluid used in regional analyses of whole brain |
| Ewing-Cobbs et al. (2008) | 3T Philips Intera | Single shot spin-echo diffusion sensitized echoplanar imaging; FOV = 240 × 240 mm2; TR = 6100 ms; TE = 84 ms; b = 1000 s/mm2; slice thickness = 3 mm with 44 axial slices | 7 mins | In-house-developed DTI design and analysis toolbox | Rostrum, renu, rostral midbody, anterior midbody, posterior midbody, isthmus, and splenium of the corpus callosum | |
| Johnson et al. (2011) | 3T Philips scanner with 8-channel head coil | Single shot spin-echo diffusion sensitized echoplanar imaging sequence; FOV = 240 × 240 mm2; TR = 6100 ms; TE = 84 ms; b = 0, and 1000 s/mm2; matrix = 256 x 256; slice thickness = 3 mm | 21 | 7 mins | Freesurfer v4.1.0 software and FMRIB Software Library (FLIRT) | Uncinate fasciculus |
| Juranek et al. (2012) | 3T Philips scanner with 8-channel phase array head coil | Single shot spin-echo diffusion sensitized echoplanar imaging sequence; FOV = 240 × 240 mm2; TR = 6100 ms; TE = 84 ms; b = 0, and 1000 s/mm2; matrix = 256 × 256; slice thickness = 3 mm | 21 | 7 mins | Freesurfer v4.0.5 software and FMRIB Software Library (BET, FLIRT, DTIFIT) | Amygdala, hippocampus |
| Kurowski et al. (2009)/ Yuan et al. (2007) | 3T Siemens Trio | Single shot spin-echo echoplanar imaging sequence; FOV = 25.6 × 25.6 cm2; TR = 6000 ms; TE = 87 ms; b = 1000 s/mm2; matrix = 128 × 128; slice thickness = 2 mm with 46 axial slices | 12 | 5:48 mins | DTIStudio 2.4 from John Hopkins University | Splenium of the corpus callosum, genu of the corpus callosum, body of the corpus callosum, ALIC, PLIC, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, left frontal white matter, right frontal white matter |
| Levin et al. (2008) | 1.5T Philips Integra | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 256 mm; TR = 10150.5 ms; TE = 90 ms; slice thickness = 2.7 mm, 0 mm gap; b = 0, and 860s/mm2 | 15 | 5:45 mins | Philips diffusion affine registration tool and Philips fiber tracking 4.1V3 Beta 4 software | Corpus callosum, genu CC, body CC, splenium CC, ALIC, PLIC, frontal lobes (ventromedial, dorsolateral), temporal lobes |
| Levin et al. (2011) | 1.5T Philips scanner | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 256 mm; TR = 10150.5 ms; TE = 90 ms; slice thickness = 2.7 mm; b = 860 s/mm2 | 15 | 5:45 mins | Philips diffusion affine registration tool and Philips fiber tracking 4.1 V3 Beta 4 software | Corpus callosum, prefrontal white matter, uncinate fasciculus, inferior longitudinal fasciculus, cingulum bundle, frontal lobes, temporal lobes |
| Max et al. (2012) | 1.5T Philips Intera | Transverse multi-slice spin-echo single shot echolpanar imaging sequence; FOV = 256mm; TR = 10150.5ms; TE = 90 ms; slice thickness = 2.7 mm, 0 mm gap; b = 2, and 860 s/mm2 | 15 | 6 mins | Philips PRIDE registration tool and Philips fiber tracking 4.1v3 Beta 2 software | Right and left frontal lobe, right and left uncinate fasciculi, right and left centrum semiovale, and right and left temporal lobes |
| Mayer et al. (2012) | 3T Siemens | Gradient echo sequence; FOV = 180x240 mmTR = 28ms; TE = 20ms; flip angle = 15°; slice thickness = 1.5mm, 88 slices; b = 0 and 860 mm230 | 30 | FMRIB Software Library (TBSS, FNIRT) and Automated Functional Neuro-Imaging (AFNI) | Left and right anterior corona radiata, left white matter tracts, left cerebral peduncle, left superior corona radiata | |
| McCauley et al. (2011) | 1.5T Philips Intera | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 256 mm; TR = 10150.5 ms; TE = 90 ms; slice thickness = 2.7 mm, 0 mm gap; b = 0, and 860 s/mm2 | 15 | 5:45 mins | Philips PRIDE registration tool and Philips fiber tracking 4.1v3 Beta 2 software | Cingulum bundle, orbitofrontal white matter, uncinate fasciculus |
| Oni et al. (2010)/ Wilde et al. (2010) | 1.5T Philips Intera | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 256 mm; TR = 10150.5 ms; TE = 90 ms; slice thickness = 2.7 mm, 0 mm gap; b = 0, and 860 s/mm2 | 15 | 5:45 mins | Philips diffusion affine registration tool and Philips fiber tracking 4.1V3 Beta 4 software | Left and right frontal lobes, left and right cingulum bundle |
| Schiebel et al. (2011) | 3T Philips Achieva | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 224 mm; TR = 6161 ms; TE = 51 ms; slice thickness = 2 mm, 0 mm gap; b = 0, and1000 s/mm2 | 32 | 5 mins | Philips diffusion affine registration tool and Philips fiber tracking 4.1V3 Beta 4 software | Ventromedial and dorsolateral frontal regions, arcuate fasciculus, inferior fronto-occipital fasciculus, inferior longlitudinal fasciculus, uncinate fasciculus, corpus callosum, cingulum bundle, ALIC, PLIC |
| Schmidt et al. (2013) | 1.5T Philips Intera | Transverse multi-slice spin-echo single shot echolpanar imaging sequence; FOV = 256mm; TR = 10150.5ms; TE = 90 ms; slice thickness = 2.7 mm, 0 mm gap; b = 0, and 860 s/mm2 | 15 | Philips PRIDE registration tool and Philips fiber tracking 4.1v3 Beta 2 software | Right and left inferior left longitudinal fasciculus, right and left uncinated fasciculus | |
| Wilde et al. (2005/2006) | 1.5T Philips Intera | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 256 mm; TR = 10150.5 ms; TE = 90 ms; slice thickness = 2.7 mm, 0 mm gap; b = 0, and 860 s/mm2 | 15 | 5:45 mins | Philips PRIDE registration tool and Philips Fiber Tracking 4.1V3 software | Genu CC, body CC, splenium CC, anterior commissure |
| Wilde et al. (2011) | 3T Philips Intera | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 224 mm; TR = 6161 ms; TE = 51 ms; slice thickness = 2 mm, 0 mm gap; b = 0, and 1000 s/mm2 | 30 | 5:45 mins | Philips PRIDE registration tool and Philips fiber tracking 4.1v3 Beta 2 software | Inferiorfronto-occipital fasciculus, inferior longitudinal fasciculus, frontal white matter, uncinate fasciculus, ALIC, PLIC, cingulum bundle |
| Wozniak et al. (2007) | 3T Siemens Trio | Dual spin echo, single shot, pulsed gradient, echoplanar imaging sequence; FOV = 256 mm; TR = 8300 ms; TE = 86 ms; 64 slices; b = 1000 s/mm2 | 12 | FMRIB Software Library (BET, FLIRT, FAST, FUGUE, FDT) | Inferior frontal mask, superior frontal mask, supracallosal mask, genu CC, midbody CC, splenium CC | |
| Wu, Wilde, Bigler, Li, et al. (2010) | 1.5T Philips Intera | Transverse multi-slice spin-echo single shot echoplanar imaging sequence; FOV = 256 mm; TR = 10150.5 ms; TE = 90 ms; 55 slices, slice thickness = 2.7 mm, 0 mm gap; b = 0, and 860 s/mm2 | 15 | 6 mins | Philips PRIDE registration tool and Philips fiber tracking 4.1v3 Beta 2 software | Genu CC, body CC, splenium CC, as well as total CC |
Note. ROI = region of interest; T = tesla; FOV = field of view; TR = repetition time; TE = echo time; mm = millimetre; ms = millisecond; CC = corpus callosum; ALIC = anterior limb of the internal capsule; PLIC = posterior limb of the internal capsule; MR = magnetic resonance; DTI = diffusion tensor imaging.