Figure 1. Single-gene expression analysis identifies two transcriptome-wide significantly differentially expressed genes between autism and control brains.
(a) Manhattan plot for 13,262 expressed genes. The threshold for transcriptome-wide significance was calculated based on 400 permutations (P<4.76 × 10−7) and is indicated by the dotted grey line. (b,c) Boxplot of gene expression in 57 controls (grey) and 47 cases (red), indicating a 1.2-fold increase for MAL and a 0.6-fold decrease for C11orf30 in cases relative to controls.