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. 2014 Dec 2;4(12):e487. doi: 10.1038/tp.2014.122

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Copyright © 2014 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Three-dimensional stereotactic surface projection z-score images for the 16-week post-intervention scans showing regions of (a) hypometabolism and (b) hypermetabolism compared with baseline scans. COMB, combined; CS, cognitive stimulation; PA, physical activity.