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. 2014 Dec 16;4(12):e489. doi: 10.1038/tp.2014.132

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Copyright © 2014 Macmillan Publishers Limited

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The effects of tetrahydrocarbazoles and analogs on the FAD-PS1-mediated enhanced ER calcium release. (a) The activity of commercially available and (b) synthesized tetrahydrocarbazoles and analogs tested at 10 μM in PS1-M146L HEK293 cells. The presented values indicate the normalized peak amplitude of CCh-evoked calcium release for cells treated with each compound for 24 h relative to the peak amplitude of DMSO-treated control (normalized ER calcium). Compounds marked with # symbol possess a certain level of toxicity, which interferes with the calcium release measurement in this assay. TP (1 μM), CPA (20 μM), TMB-8 (50 μM) and Bepridil (20 μM), all lowering the amount of calcium release from ER, were used as positive controls. (n.s. non-significant; *P<0.05, **P<0.01 and ***P<0.001; n=4). CCh, carbachol; CPA, cyclopiazonic acid; DMSO, dimethyl sulfoxide; ER, endoplasmic reticulum; FAD-PS1, familial Alzheimer's disease presenilin 1; TMB, 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester; TP, Thapsigargin.