Figure 1.
Effects of Ang II/losartan/losartan + AngII with different concentrations on expressions of MMP-9 and TIMP-1 protein in rat aortic vascular smooth muscle cells (24-h incubation). (A) Lanes 1–5 presented as blank, AngII 10−9 M, AngII 10−8 M, AngII 10−7 M and AngII 10−6 M, respectively. (B) Lanes 1–5 presented as blank, losartan 10−7 M, losartan 10−6 M, losartan 10−5 M and losartan 10−4 M, respectively. (C) Lane 1 presented as blank, and lanes 2–5 presented as added losartan 10−7 M, losartan 10−6 M, losartan 10−5 M and losartan 10−4 M based on AngII 10−6 M, respectively. MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor of metalloproteinase-1; AngII, angiotensin II.