Table II.
Comparison of the gradation values of the obtained protein bands (Fig. 1B) as a result of different losartan concentrations towards the expressions of MMP-9 and TIMP-1 proteins in rat aortic vascular smooth muscle cells.
| Groups | Control | 10−7 M | 10−6 M | 10−5 M | 10−4 M |
|---|---|---|---|---|---|
| MMP-9 gradation | 1 | 0.90±0.10 | 0.72±0.11a | 0.58±0.13a | 0.38±0.15a |
| TIMP-1 gradation | 1 | 1.26±0.13a | 1.63±0.13a | 1.90±0.13a | 2.19±0.13a |
| MMP-9/TIMP-1 | 1 | 0.71±0.06a | 0.44±0.07a | 0.31±0.05a | 0.17±0.07a |
a
P<0.01 as compared with the control group. Values are presented as the mean ± standard deviation (n=4).
MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor of metalloproteinase-1.