Table III.
Comparison of the gradation values of the obtained protein bands (Fig. 1C) as a result of the combination of different losartan concentrations and angiotensin II towards the expressions of MMP-9 and TIMP-1 proteins in rat aortic vascular smooth muscle cells.
| Groups | Control | 10−7 M | 10−6 M | 10−5 M | 10−4 M |
|---|---|---|---|---|---|
| MMP-9 gradation | 1 | 0.93±0.07 | 0.7±0.06a | 0.59±0.05a | 0.37±0.04a |
| TIMP-1 gradation | 1 | 1.28±0.09a | 1.61±0.14a | 1.88±0.17a | 2.01±0.19a |
| MMP-9/TIMP-1 | 1 | 0.73±0.06a | 0.43±0.04a | 0.31±0.04a | 0.18±0.02a |
a
P<0.01 as compared with the control group. Values are presented the mean ± standard deviation (n=4).
MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor of metalloproteinase-1.