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. 2014 Nov 27;11(3):1655–1660. doi: 10.3892/mmr.2014.3011

Figure 2.

Figure 2

Tre enhances MG132-induced macroautophagy. (A) Inhibition of the ubiquitin-proteasome system significantly activated macroautophagy, and 50 mmol/l Tre further increased the number of LC3+ and Lysotracker-positive autolysosomes (white arrows) induced by MG132. Original magnification, ×400. (B) In A53T α-synuclein-overexpressing PC12 cells, 500 nmol/l MG132 significantly increased LC3-II expression (P<0.01). Treatment with 50 mmol/l Tre further upregulated MG132-induced LC3-II expression. **P<0.01 vs. control group, ##P<0.01 vs. MG132 group. LC3, microtubule-associated protein 1A/1B light chain; Tre, trehalose.