Table 1.
The relative effect of MAPK inhibitors on NaF- and TPA-induced CXCL8 release
| Inhibitor | % inhibition of CXCL8 release
|
|
|---|---|---|
| NaF | TPA | |
| PD98059 | 43.6 | 55.4 |
| SB202190 | 41.0 | 12.4ns |
| SP600125 | 58.5 | 32.6ns |
Notes: The table compares the percent inhibition of CXCL8 release by the p38 inhibitor SB202190 (10 μM), the ERK1/2 inhibitor PD98059 (25 μM), and the JNK1/2-inhibitor SP600125 (20 μM) in A549 cells exposed to 3.75 mM of NaF8 or 100 nM of TPA for 20 hours. nsNot statistically significant. Data from Refsnes M, Skuland T, Schwarze PE, Øvrevik J, Låg M. Fluoride-induced IL-8 release in human epithelial lung cells: relationship to EGF-receptor-, SRC- and MAP-kinase activation. Toxicol Appl Pharmacol. 2008;227(1):56–67.8
Abbreviations: MaPK, mitogen-activated protein kinase; NaF, sodium fluoride; TPA, 12-O-tetradecanoylphorbol-13-acetate; CXCL8, interleukin-8; ERK, extracellular signal-regulated kinase; JNK, c-jun-N-terminal kinase.