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. Author manuscript; available in PMC: 2014 Dec 18.
Published in final edited form as: Pharmacogenomics. 2012 Apr;13(5):543–554. doi: 10.2217/pgs.12.21

Figure 1. Missense variants found in the Jewish population.

Figure 1

The structure of human POR [19] is shown, gray ribbons indicate the peptide backbone. FAD (yellow) and FMN (blue–gray) cofactors and NADP(H) coenzyme (only 2’,5’-ADP of NADP+ was structurally resolved, pink) are shown in stick configuration. Amino acid residues corresponding to Ashkenazi Jewish variants (red) and Moroccan Jewish variants (blue) are shown in space-filling configuration (see inset labels). FAD: Flavin adenine dinucleotide; FMN: Flavin mononucleotide.