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Structures of the two novel analogues 8,9-dihydro-8R-hydroxy-LTM (16) and 8,9-dihydro-8R-methoxy-LTM (17). (A) Key 1H–1H COSY and HMBC correlations of 16 and 17 supporting their structural assignments. (B) MM2 energy-minimized configurations of model 12-membered macrolides with an 8S- or 8R-hydroxyl group, depicting the predicted H-7/H-8 dihedral angels that support the 8R absolute configurations for 16 and 17 on the basis of the H-7/H-8 coupling constants.
