Table 1. Modification Rates (±standard deviations) for Peptide Fragments, LMW Aβ40, and Aβ40 Fibrils and Protection Factors for LMW Aβ40 and Aβ40 Fibrilsa.
| residue | fragments (s−1) | LMW (s−1) | LMW PF | fibrils (s−1) | fibril PF |
|---|---|---|---|---|---|
| F4 | 5.5 (−) | 3.1 (1.6) | 2 | 1.4 (0.4) | 4 |
| Y10 | 7 (2) | 3.0 (0.5) | 2 | 1.7 (0.4) | 4 |
| HI3 | 4.7 (0.1) | 2.5 (0.6) | 2 | 0.11 (0.04) | 40 |
| HI4 | 5.4 (0.5) | 2.8 (0.7) | 2 | 0.3 (0.1) | 20 |
| L17 | 4.5 (−) | 2.7 (−) | 2 | 0.15 (−) | 30 |
| F19 | 6.2 (−) | 2.7 (0.4) | 2 | 0.08 (0.01) | 80 |
| F20 | 7 (3) | 4.1 (−) | 2 | 0.94 (−) | 7 |
| V24 | 5.0 (0.1) | 4.7 (−) | 1 | 0.31 (−) | 20 |
| K28 | 11 (2) | 1.5 (0.3) | 7 | 0.19 (0.09) | 60 |
| 131 | 7.5 (−) | 5.7 (0.9) | 1 | 0.5 (0.2) | 20 |
| 132 | 7.6 (0.3) | 0.8 (0.5) | 10 | 0.13 (0.04) | 60 |
| L34 | 5 (1) | 0.9 (0.5) | 6 | 0.06 (0.03) | 90 |
| M35 | 15 (6) | 12 (−) | 1 | 2.3 (0.2) | 6 |
| V36/39/40 | 5.4 (0.6) | 0.6 (0.1) | 9 | 0.01 (0.01) | 400 |
a
A propagation of error analysis is provided in Table S4 of the Supporting Information.