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| inhibitora | carbon skeleton | IC50 (nM) |
|---|---|---|
| oleoyl-CoA | 18:1 (Δ9) | 380 ± 5 |
| palmitoleoyl-CoA | 16:1 (Δ9) | 430 ± 40 |
| myristoyl-CoA | 14:0 | 580 ± 70 |
| lauroyl-CoA | 12:0 | 1100 ± 130 |
Reaction was fixed at the Km,app values for both acetyl-CoA (39 μM) and tyramine (12 μM) while varying the concentration of the long-chain acyl-CoA inhibitor. Kinetic constants are reported with the standard error (n = 3).
