Figure 1.

Representations of conserved residues lining the substrate cavity in four isoforms of soybean lipoxygenase (gray, bold letters are residue numbers of SBL1 and smaller numbers refer to residue positions in soybean lipoxygenase isoforms LOX-3, VLXB, and VLXD.) Protein side chain ligands to iron (carbon in cyan) are shown, together with a linoleic acid models (purple). A conserved Arg (gray) occurs in a subcavity extension. Catalytic iron is colored salmon and the water O ligand, dark gray. Adapted with permission from Figure 5A, ref (4), 2006 John Wiley & Sons.