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. 2014 Dec 12;9:5837–5847. doi: 10.2147/IJN.S73961

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© 2014 Zhu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vivo teratoma formation by injection of induced iPSCs.

Notes: (A) Teratoma formation on NOD-SCID mice. (B) HE staining analysis of three germ layers (green arrow) in teratoma sections. Colony C1: endoderm (gut epithelium); mesoderm (cartilage); ectoderm (melanocyte). Colony C2: endoderm (secretory epithelium); mesoderm (cartilage); ectoderm (neuroepithelial rosettes). Scale bar =100 μm.

Abbreviations: HE, hematoxylineosin; iPSC, induced pluripotent stem cell; NOD-SCID, nonobese diabetic-severe combined immunodeficient.