Table 2.

Treatment groups in included trials

Study Treatment period	Intervention 1	Intervention 2	Intervention 3	Intervention 4
Pegaptanib versus control
VISION 2004 2 years; re-randomized at end of first year	0.3 mg pegaptanib every 6 weeks	1.0 mg pegaptanib every 6 weeks	3.0 mg pegaptanib every 6 weeks	Sham every 6 weeks
Ranibizumab versus control
ANCHOR 2006 2 years	0.3 mg ranibizumab monthly plus sham verteporfin PDT	0.5 mg ranibizumab monthly plus sham verteporfin PDT	Sham intravitreal injection plus verteporfin PDT	-
MARINA 2006 2 years	0.3 mg ranibizumab monthly	0.5 mg ranibizumab monthly	Sham intravitreal injection monthly	-
PIER 2008 2 years	0.3 mg ranibizumab monthly for 3 months, then every 3 months	0.5 mg ranibizumab monthly for 3 months, then every 3 months	Sham intravitreal injection monthly for 3 months, then every 3 months	-
Bevacizumab versus control
ABC 2010 1 year	1.25 mg bevacizumab given first three injections every 6 weeks, then as needed	Standard therapy (0.3 mg pegaptanib every six weeks, verteporfin PDT, or sham injection)	-	-
Sacu 2009 1 year	1.0 mg bevacizumab monthly for 3 months, then as needed	Verteporfin PDT plus same day 4 mg triamcinolone acetonide	-	-
Bevacizumab versus ranibizumab
CATT 2011 2 years; re-randomized at end of first year	1.25 mg bevacizumab monthly for 1 year; at 1 year, re-randomization to ranibizumab monthly or variable dosing	0.5 mg ranibizumab monthly for 1 year; at 1 year, re-randomization to ranibizumab monthly or variable dosing	1.25 mg bevacizumab as needed after first injection for 2 years	0.5 mg ranibizumab as needed after first injection for 2 years
IVAN 2013 2 years; ongoing	1.25 mg bevacizumab monthly for 2 years	0.5 mg ranibizumab monthly for 2 years	1.25 mg bevacizumab monthly for 3 months, then as needed in 3 month cycles	0.5 mg ranibizumab monthly for 3 months, then as needed in 3 month cycles
Biswas 2011 18 months	1.25 mg bevacizumab monthly for 3 months, then as needed	0.5 mg ranibizumab monthly for 3 months, then as needed	-	-
GEFAL 2013 1 year	1.25 mg bevacizumab; maximum of one injection per month	0.5 mg ranibizumab; maximum of one injection per month	-	-
MANTA 2013 1 year	1.25 mg bevacizumab monthly for 3 months, then as needed	0.5 mg ranibizumab monthly for 3 months, then as needed	-	-
Subramanian 2010 1 year	0.05 ml bevacizumab monthly for 3 months, then as needed	0.05 ml ranibizumab monthly for 3 months, then as needed	-	-

PDT: photodynamic therapy