Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Gain of 15 letters or more visual acuity at one year	6	2446	Risk Ratio (M-H, Random, 95% CI)	0.90 [0.73, 1.11]
2 Gain of 15 letters or more visual acuity at two years	2		Risk Ratio (M-H, Random, 95% CI)	Subtotals only
2.1 Participants in groups as randomized at baseline	2	1547	Risk Ratio (M-H, Random, 95% CI)	0.84 [0.64, 1.11]
2.2 Participants remaining in same groups after re-randomization	2	1295	Risk Ratio (M-H, Random, 95% CI)	0.84 [0.64, 1.11]
3 Loss of fewer than 15 letters visual acuity at one year	6	2446	Risk Ratio (M-H, Random, 95% CI)	1.00 [0.98, 1.02]
4 Loss of fewer than 15 letters visual acuity at two years	2		Risk Ratio (M-H, Random, 95% CI)	Subtotals only
4.1 Participants in groups as randomized at baseline	2	1547	Risk Ratio (M-H, Random, 95% CI)	0.97 [0.94, 1.00]
4.2 Participants remaining in same groups after re-randomization	2	1295	Risk Ratio (M-H, Random, 95% CI)	0.98 [0.94, 1.01]
5 Visual acuity better than 20/200 at one year	4	2026	Risk Ratio (M-H, Random, 95% CI)	0.98 [0.96, 1.01]
6 Visual acuity better than 20/200 at two years	2		Risk Ratio (M-H, Random, 95% CI)	Subtotals only
6.1 Participants in groups as randomized at baseline	2	1547	Risk Ratio (M-H, Random, 95% CI)	1.00 [0.95, 1.06]
6.2 Participants remaining in same groups after re-randomization	2	1295	Risk Ratio (M-H, Random, 95% CI)	1.01 [0.95, 1.06]
7 Mean change in visual acuity at one year (number of letters)	6	2446	Mean Difference (IV, Random, 95% CI)	−0.51 [−1.64, 0.62]
8 Mean change in visual acuity at two years (number of letters)	2	1295	Mean Difference (IV, Random, 95% CI)	−1.15 [−2.82, 0.51]
9 Reduction in central retinal thickness at one year	4	1995	Mean Difference (IV, Random, 95% CI)	−13.97 [−26.52, −1.
10 Reduction in central retinal thickness at two years	2	1199	Mean Difference (IV, Random, 95% CI)	−12.40 [−33.83, 9.
11 No problems in quality of life domain at one year	1		Risk Ratio (M-H, Random, 95% CI)	Totals not selected
11.1 Mobility	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
11.2 Self care	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
11.3 Usual activities	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
11.4 Pain/discomfort	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
11.5 Anxiety/depression	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
12 No problems in quality of life domain at two years	1		Risk Ratio (M-H, Random, 95% CI)	Totals not selected
12.1 Mobility	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
12.2 Self care	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
12.3 Usual activities	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
12.4 Pain/discomfort	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]
12.5 Anxiety/depression	1		Risk Ratio (M-H, Random, 95% CI)	0.0 [0.0, 0.0]