Central Illustration.

Morphological and Functional Features and Outcomes of HCM Owing to Thin-Filament Mutations

(Top) Hearts with thin-filament (left, blue/gray) and thick-filament (right, light blue/gray) mutations, highlighting the main morphological and functional features of the 2 groups (1 arrow = a poorly represented feature, 2 arrows = a moderately represented feature, and 3 arrows = a highly prevalent feature). (Bottom) Outcome of thin-filament and thick-filament HCM. Adverse remodeling is more common in thin-filament patients and may lead to either restrictive or hypokinetic morphological and functional end-stage phenotypes. Both are more represented in thin-filament patients and are related to increased prevalence of heart failure symptoms in the thin-filament cohort. HCM = hypertrophic cardiomyopathy; LV = left ventricular.