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. 2014 Dec 23;64(24):2589–2600. doi: 10.1016/j.jacc.2014.09.059

Figure 2.

Figure 2

Genetic Basis of Thin-Filament HCM

Exons and structural and functional domains of cardiac troponin T (cTnT) and I (cTnI), tropomyosin (Tm), and actin, showing mutation sites identified in the study cohort. Black, certainly pathogenic mutations (see Methods); slate-grey, mutations likely to be pathogenic. For mutations carried by more than 1 patient, the total number of carriers is indicated. HCM = hypertrophic cardiomyopathy.