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. 2014 Dec 23;64(24):2589–2600. doi: 10.1016/j.jacc.2014.09.059

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Clinical and Instrumental Outcomes in Thick- Versus Thin-Filament HCM

(A) Kaplan-Mayer curve illustrating survival free of progression to severe heart failure (New York Health Association [NYHA] functional classes III/IV). (B) Survival free of adverse left ventricular (LV) remodeling and dysfunction during follow-up, defined as progression to LV ejection fraction (EF) <50% or toward restrictive LV filling pattern. (C) Lifelong likelihood of advanced LV dysfunction (defined as in B) in relation to genetic status. The probability values are calculated with the log-rank test comparing thin-filament versus thick-filament survival curves. HCM = hypertrophic cardiomyopathy; NYHA = New York Heart Association.