Table 3.

Subjective effects (mean ± SEM) measured as peak change from pre-capsule baseline on the Profile of Mood States (POMS) following placebo, 150 mg bupropion, 300 mg bupropion, and 20 mg d- amphetamine. Data are shown for 30 participants (data from 3 participants were lost). Significant main effects of drug treatment were found for all values listed.

	Placebo	150 mg bupropion	300 mg bupropion	20 mg d-amphetamine
Profile of Mood
States
Friendliness	−1.58 ± 0.88	−0.87 ± 1.07	−0.67 ± 0.83	2.55 ± 0.95*
Anxiety	0.03 ± 0.52	1.03 ± 0.60	1.88 ± 0.68	3.15 ± 1.07*
Fatigue	0.58 ± 0.88	−0.39 ± 0.80	−2.45 ± 0.68*	−2.36 ± 0.77
Elation	−0.94 ± 0.69	−0.84 ± 0.66	0.03 ± 0.70	4.42 ± 0.92*
Vigor	−0.27 ± 0.94	0.07 ± 0.92	2.52 ± 0.95	8.18 ± 1.44*
Arousal	−1.03 ± 1.78	0.36 ± 1.82	5.70 ± 1.68*	13.67 ± 2.26*
ARCI
A	0.49 ± 0.27	0.58 ± 0.30	1.50 ± 0.38	4.25 ± 0.46*
BG	−0.67 ± 0.37	−0.23 ± 0.40	0.09 ± 0.47	2.69 ± 0.65*
MBG	−0.09 ± 0.42	0.41 ± 0.48	1.46 ± 0.61	5.81 ± 0.88*
PCAG	0.97 ± 0.70	−0.21 ± 0.59	−0.31 ± 0.72	−1.03 ± 0.78*
Drug Effects
Questionnaire
Feel	0.19 ± 0.04	0.16 ± 0.03	0.32 ± 0.04*	0.52 ± 0.04*
Like	−0.04 ± 0.03	−0.03 ± 0.03	0.03 ± 0.04*	0.13 ± 0.05*
High	0.09 ± 0.02	0.08 ± 0.03	0.18 ± 0.04	0.33 ± 0.05*
Want More	0.06 ± 0.05	0.16 ± 0.06	0.17 ± 0.06*	0.42 ± 0.07*

^*indicates significant difference from placebo ( p ≤ 0.01).