Figure 5. Effects of T-type Ca²⁺ channel blockers on the contractile activity of pressurized lymphatic vessels.

A, original recording of the effect of mibefradil (100 nm administered to a vessel at a luminal pressure of 6 cmH₂O. B, Ni²⁺ significantly reduced the increase in contraction frequency caused by increases in applied pressure (left), but did not change the contraction amplitude (right). C, similarly, mibefradil (100 nm) significantly inhibited the frequency–pressure relationship (left), without affecting the force–pressure relationship (right) (n = 4, *P < 0.05).